Bulk Inquiry
Tilfrinib
- Soluble in DMSO and EtOH
- MF: C17H13N3O
- MW: 275.3
Description
Tilfrinib is a potent inhibitor of breast tumor kinase (Brk/PTK6). It suppresses PTK6-dependent signaling and shows antiproliferative activity in breast cancer cell lines.
Brk/PTK6 is a non-receptor tyrosine kinase implicated in breast cancer growth, migration and survival signaling. Tilfrinib is useful for studying PTK6 kinase dependency and Brk-targeted anticancer pharmacology.
Key Features
- Brk/PTK6 tyrosine kinase inhibitor
- Reported IC50: 3.15 nM
- Shows antiproliferative activity in breast tumor cell lines
- Targets kinase signaling linked to breast cancer progression
Applications
- PTK6/Brk kinase pharmacology
- Breast cancer signaling studies
- Cell proliferation and survival assays
- Tyrosine kinase inhibitor profiling
More Information
| Parent CAS No. | 1600515-49-8 |
|---|---|
| Chemical Name | 3-(9H-pyrido[2,3-b]indol-4-ylamino)phenol |
| SMILES | C1(O)=CC=CC(NC2=C3C4=C(NC3=NC=C2)C=CC=C4)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H13N3O/c21-12-5-3-4-11(10-12)19-15-8-9-18-17-16(15)13-6-1-2-7-14(13)20-17/h1-10,21H,(H2,18,19,20) |
| InChiKey | RXPZOSHFGJWSLQ-UHFFFAOYSA-N |
| CID | 76332983 |
| Short Description | Brk inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1136 | SU 6656 |
From $132.00 |
| 1392 | Dasatinib |
From $99.00 |
| 1395 | Lapatinib ditosylate |
From $88.00 |
| 1407 | SKI 606 |
From $82.50 |
| 1456 | AZD0530 difumarate |
From $115.50 |
| 1526 | Neratinib |
From $88.00 |
| 1537 | CP 724714 |
From $88.00 |
| 1544 | BIBW 2992 |
From $55.00 |
| 1892 | 1-NM-PP1 |
From $104.50 |
| 1986 | AST 1306 tosylate |
From $99.00 |
| 2053 | TAK 165 |
From $66.00 |
| 2097 | CGP 77675 |
From $71.50 |
| 2381 | WH-4-023 |
From $99.00 |
| 2731 | STAT5 Inhibitor 1 [285986-31-4] |
From $99.00 |
