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STAT5 Inhibitor 1 [285986-31-4]

Axon 2731
CAS:  285986-31-4
Purity:  98%
  • Soluble in DMSO
  • MF:  C16H11N3O3
  • MW:  293.28

Description

STAT5 Inhibitor 1 [CAS 285986-31-4] is a nonpeptidic small-molecule inhibitor of the transcription factor STAT5, with a reported IC50 value of 47 µM for STAT5β-domain function. It inhibits STAT5 DNA binding in vitro and reduces STAT5 activation in cellular systems.

The compound is used as a mechanistic probe for investigating STAT5-dependent transcription, cytokine signaling and immune-cell differentiation. Reported studies include suppression of STAT5 phosphorylation and effects on inducible regulatory T-cell generation; because cellular activity is in the micromolar range, concentration-matched controls are recommended.

Key Features

  • Nonpeptidic STAT5 pathway inhibitor
  • IC50: 47 µM for STAT5β-domain function
  • Inhibits STAT5 DNA binding
  • Reduces cellular STAT5 activation

Applications

  • STAT5 transcription-factor research
  • Cytokine signaling studies
  • STAT5 DNA-binding assays
  • Regulatory T-cell differentiation research
  • Cancer-cell signaling studies

More Information

Parent CAS No. 285986-31-4
Chemical Name N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
SMILES C1N=CC(C(=O)N/N=C/C2C(=O)C3C=CC=CC=3OC=2)=CC=1
MFCD N.A.
InChi InChI=1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21)/b18-9+
InChiKey DAVIKTBRCQWOGT-GIJQJNRQSA-N
CID 9566174
Short Description STAT5 inhibitor

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