Kinases (Tyrosine Specific Protein)

Tyrosine specific kinases form a large family of enzymes that are responsible for catalyzing the transfer of ATP to specific tyrosine residues in target proteins. In turn, the phosphorylation of tyrosine residues causes a change in the function of the protein that they are contained in. They function in a variety of processes, signal transduction pathways, and actions, and may be responsible for key events in the body[1]. Axon Ligands™ that interact with tyrosine specific enzymes that are part of the JAK/STAT signaling pathway have been categorized independently. The remainder of Axon Ligands™ that lack interactions with tyrosine kinases of this particular signaling pathway are listed here, grouped on the basis of their selectivity.


[1] Receptor tyrosine kinase signaling: a view from quantitative proteomics. J. Dengjel,I. Kratchmarova, B. Blagoev. Mol. Biosyst. 2009, 5, 1112-1121.

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Axon ID Name Description From price
1892 1-NM-PP1 Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) €95.00
1698 A 770041 Orally active src-family selective lck inhibitor €140.00
1378 AG 490 JAK2 inhibitor €65.00
2031 AIM 100 Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2) €95.00
2005 ASP 3026 Inhibitor of the oncogenic fusion kinase EML4-ALK €80.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
2226 AVL 292 Potent, selective, covalent BTK inhibitor €110.00
1778 AZ 960 JAK2 inhibitor €95.00
1456 AZD 0530 difumarate Inhibitor of SRC and ABL tyrosine kinases €70.00
1955 Baricitinib Inhibitor of JAK1 and JAK2 €70.00
2978 Brigatinib Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor €80.00
3671 CEP-33779 Potent, selective and orally bioavailable JAK2 inhibitor  Recently added €95.00
2775 Cerdulatinib Orally active dual Syk/JAK inhibitor €85.00
2018 CGI 1746 Inhibitor of Bruton's tyrosine kinase (BTK) €50.00
2097 CGP 77675 Src Family kinase (SFK) inhibitor €65.00
1338 CP 690550 JAK3 inhibitor €60.00
2992 CTx-0294885 Broad-spectrum kinase inhibitor €90.00
1681 CYT 387 JAK1 and JAK2 inhibitor €90.00
1392 Dasatinib Bcr-Abl and Src tyrosine kinase inhibitor €90.00
2574 Defactinib Orally available second generation inhibitor of FAK and PYK2 €80.00
3717 GSK2256098 FAK inhibitor  Recently added Inquire
2121 INNO 406 Dual Bcr-Abl and Lyn kinase inhibitor €85.00
1843 JAK2 inhibitor 13 JAK2 inhibitor €110.00
2294 KRCA 0008 Potent and selective dual ALK/ACK1 inhibitor with good drug-like properties €95.00
2862 LFM-A13 Inhibitor of Bruton's tyrosine kinase (BTK) €90.00
3270 Lj-1-60 Fyn inhibitor targeting the Fyn/Stat3 pathway €90.00
2554 LY 2784544 Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F) €95.00
1494 MK 1775 Wee1 kinase inhibitor €80.00
1941 MLR 1023 Selective allosteric activator of Lyn kinase €95.00
3466 MT-802 Potent and rapid degrader of BTK; PROTAC €280.00

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