Kinases (Tyrosine Specific Protein)
Tyrosine specific kinases form a large family of enzymes that are responsible for catalyzing the transfer of ATP to specific tyrosine residues in target proteins. In turn, the phosphorylation of tyrosine residues causes a change in the function of the protein that they are contained in. They function in a variety of processes, signal transduction pathways, and actions, and may be responsible for key events in the body[1]. Axon Ligands™ that interact with tyrosine specific enzymes that are part of the JAK/STAT signaling pathway have been categorized independently. The remainder of Axon Ligands™ that lack interactions with tyrosine kinases of this particular signaling pathway are listed here, grouped on the basis of their selectivity.
[1] Receptor tyrosine kinase signaling: a view from quantitative proteomics. J. Dengjel,I. Kratchmarova, B. Blagoev. Mol. Biosyst. 2009, 5, 1112-1121.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1892 | 1-NM-PP1 | Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) | €95.00 | |
| 1698 | A 770041 | Orally active src-family selective lck inhibitor | €140.00 | |
| 1378 | AG 490 | JAK2 inhibitor | €65.00 | |
| 2031 | AIM 100 | Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2) | €95.00 | |
| 2005 | ASP 3026 | Inhibitor of the oncogenic fusion kinase EML4-ALK | €80.00 | |
| 2219 | AT 9283 | Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) | €85.00 | |
| 2226 | AVL 292 | Potent, selective, covalent BTK inhibitor | €120.00 | |
| 1778 | AZ 960 | JAK2 inhibitor | €95.00 | |
| 1456 | AZD 0530 difumarate | Inhibitor of SRC and ABL tyrosine kinases | €70.00 | |
| 1955 | Baricitinib | Inhibitor of JAK1 and JAK2 | €70.00 | |
| 2978 | Brigatinib | Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor | €80.00 | |
| 2775 | Cerdulatinib | Orally active dual Syk/JAK inhibitor | €85.00 | |
| 2018 | CGI 1746 | Inhibitor of Bruton's tyrosine kinase (BTK) | €50.00 | |
| 2097 | CGP 77675 | Src Family kinase (SFK) inhibitor | €95.00 | |
| 1338 | CP 690550 | JAK3 inhibitor | €60.00 | |