Bruton’s tyrosine kinase (BTK; EC is a non-receptor tyrosine kinase belonging to the Tec family of kinases (TFKs), which form the second largest family of cytoplasmic tyrosine kinases in mammalian cells and include, in addition to BTK, Tec, Itk, Txk (also known as Rlk), and bone marrow tyrosine kinase gene on chromosome X (Bmx). Btk is critical for B-cell development, differentiation, and signaling. Moreover, BTK expression is assumed to be a prerequisite for B-cell proliferation and survival. Btk is the only member of the TFKs reported to be associated with human disease (primary immunodeficiency, named X-linked agammaglobulinemia (XLA) and a milder form: X-linked immunodeficiency (Xid))[1].  

[1] A.J. Mohamed. Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immun. Reviews. 2009, 228, 58-73.

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Axon ID Name Description From price
4141 Acalabrutinib Orally active, irreversible, and highly selective second-generation BTK inhibitor Inquire
2226 AVL 292 Potent, selective, covalent BTK inhibitor €110.00
2018 CGI 1746 Inhibitor of Bruton's tyrosine kinase (BTK) €50.00
2862 LFM-A13 Inhibitor of Bruton's tyrosine kinase (BTK) €90.00
3466 MT-802 Potent and rapid degrader of BTK; PROTAC €280.00
1858 PCI 32765 Inhibitor of Bruton's tyrosine kinase (BTK) €60.00
3869 RN486 Selective and reversible inhibitor of Bruton's tyrosine kinase (BTK) Inquire

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