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MT-802
Axon 3466
CAS:
2231744-29-7
Purity:
97%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C41H41N9O8
- MW: 787.82
Description
The PROTAC MT-802 is a potent and rapid degrader of BTK with a DC50 value of 9.1 nM with maximal degradation being observed by 250 nM. MT-802 showed IC50 values of 46.9 nM and 20.9 nM for wild-type BTK and C481S BTK, respectively.
More Information
| Parent CAS No. | 2231744-29-7 |
|---|---|
| Chemical Name | 2-(2-(2-(4-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)acetamide |
| SMILES | C1C=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=1NC(=O)COCCOCCN1CCC(N2N=C(C3C=CC(OC4C=CC=CC=4)=CC=3)C3C(N)=NC=NC2=3)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C41H41N9O8/c42-37-35-36(25-6-9-29(10-7-25)58-28-4-2-1-3-5-28)47-50(38(35)44-24-43-37)27-14-16-48(17-15-27)18-19-56-20-21-57-23-34(52)45-26-8-11-30-31(22-26)41(55)49(40(30)54)32-12-13-33(51)46-39(32)53/h1-11,22,24,27,32H,12-21,23H2,(H,45,52)(H2,42,43,44)(H,46,51,53) |
| InChiKey | AJTLGUJXIKEZCQ-UHFFFAOYSA-N |
| CID | 138108326 |
| Short Description | BTK degrader |
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