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CC-885
- Soluble in DMSO
- MF: C22H21ClN4O4
- MW: 440.88
Description
Cereblon (CRBN) modulator with potent anti-tumour activity which is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. CC-885 exhibits potent anti-proliferative activity in patient-derived acute myeloid leukaemia (AML) tumour cell lines.
More Information
| Parent CAS No. | 1010100-07-8 |
|---|---|
| Chemical Name | 1-(3-chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea |
| SMILES | N(C1=CC=C(C)C(Cl)=C1)C(NCC1C=CC2=C(C=1)CN(C1CCC(=O)NC1=O)C2=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C22H21ClN4O4/c1-12-2-4-15(9-17(12)23)25-22(31)24-10-13-3-5-16-14(8-13)11-27(21(16)30)18-6-7-19(28)26-20(18)29/h2-5,8-9,18H,6-7,10-11H2,1H3,(H2,24,25,31)(H,26,28,29) |
| InChiKey | DOEVCIHTTTYVCC-UHFFFAOYSA-N |
| CID | 24788636 |
| Short Description | Cereblon (CRBN) modulator |
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