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RITA
- NSC 652287
- Soluble in DMSO
- MF: C14H12O3S2
- MW: 292.37
Description
RITA (NSC652287) is a small-molecule p53 pathway activator reported to disrupt p53-MDM2 interaction and reactivate p53-dependent transcriptional responses. It promotes p53-mediated cell-cycle arrest and apoptosis in suitable tumor models.
The p53-MDM2 axis is a central tumor suppressor pathway controlling DNA damage responses, apoptosis and cellular senescence. RITA is useful for studying pharmacological p53 activation and MDM2-dependent regulation in oncology research.
Key Features
- p53 pathway activator
- Reported inhibitor of p53-MDM2 interaction
- Promotes p53-dependent transcriptional responses
- Relevant to apoptosis and tumor suppressor research
Applications
- p53 activation assays
- MDM2-p53 interaction studies
- Cancer cell apoptosis models
- DNA damage response research
More Information
| Parent CAS No. | 213261-59-7 |
|---|---|
| Chemical Name | (5,5'-(furan-2,5-diyl)bis(thiophene-5,2-diyl))dimethanol |
| SMILES | O1C(C2SC(CO)=CC=2)=CC=C1C1SC(CO)=CC=1 |
| MFCD | MFCD03235294 |
| InChi | InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2 |
| InChiKey | KZENBFUSKMWCJF-UHFFFAOYSA-N |
| CID | 374536 |
| Short Description | MDM2 inhibitor |
References
- MN Saha et al. RITA Inhibits Multiple Myeloma Cell Growth through Induction of p53-Mediated Caspase-Dependent Apoptosis and Synergistically Enhances Nutlin-Induced Cytotoxic Responses. Mol. Cancer Ther. 2010, 9, 3041.
- N Issaeva et al. Small molecule RITA binds to p53, blocks p53−HDM-2 interaction and activates p53 function in tumors. Nature Med. 2004, 10, 1321-1328.
- MN Saha et al. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma. PLoS One. 2012, 7(1), e30215.
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