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RO 3306
- Soluble in DMSO
- MF: C18H13N3OS2
- MW: 351.45
Description
RO 3306 is a selective CDK1 inhibitor with reported Ki values of 35 nM for CDK1/cyclin B and 110 nM for CDK1/cyclin A. RO3306 induces cell cycle arrest and actively enhances downstream p53 signaling to promote apoptosis in AML cell lines.
CDK1 is the central driver of G2/M progression and mitotic entry. RO 3306 is widely used to synchronize cells at the G2/M boundary and to investigate checkpoint signaling, mitotic regulation and p53-linked cell-cycle responses.
Key Features
- Selective inhibitor of CDK1 kinase complexes
- Ki: 35 nM for CDK1/cyclin B and 110 nM for CDK1/cyclin A
- Induces reversible G2/M cell-cycle arrest
- Useful for mitotic synchronization and checkpoint studies
Applications
- Cell-cycle and mitosis research
- CDK1 kinase assays
- G2/M checkpoint synchronization
- DNA damage and p53 pathway studies
More Information
| Parent CAS No. | 872573-93-8 |
|---|---|
| Chemical Name | 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one |
| SMILES | C1(CNC2=NC(=O)/C(=C/C3C=CC4=NC=CC=C4C=3)/S2)SC=CC=1 |
| MFCD | MFCD17392573 |
| InChi | InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10- |
| InChiKey | XOLMRFUGOINFDQ-YBEGLDIGSA-N |
| CID | 135400873 |
| Short Description | CDK1 inhibitor |
References
- LT Vassilev et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci USA. 2006, 103(28), 10660–10665.
- K Kojima et al. The CDK1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 2009, 100(6), 1128–1136.
- List of publications using RO 3306 (Axon 1530) purchased from Axon Medchem
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