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Dinaciclib
- SCH 727965
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H28N6O2
- MW: 396.49
Description
Dinaciclib is a potent and selective cyclin-dependent kinase (CDK) inhibitor targeting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM, respectively.
CDKs regulate cell-cycle transitions, transcription and survival signaling. Dinaciclib is useful for studying combined inhibition of cell-cycle and transcriptional CDKs in antineoplastic pharmacology.
Key Features
- Potent inhibitor of CDK1, CDK2, CDK5 and CDK9
- IC50: 3, 1, 1 and 4 nM for CDK1/2/5/9
- Targets both cell-cycle and transcriptional CDK biology
- Relevant antineoplastic pathway compound
Applications
- CDK kinase assay development
- Cell-cycle arrest and apoptosis studies
- Transcriptional CDK pathway research
- Cancer pharmacology and combination studies
More Information
| Parent CAS No. | 779353-01-4 |
|---|---|
| Chemical Name | (S)-3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide |
| SMILES | N1(C2C=C(NCC3=CC=C[N+]([O-])=C3)N3N=CC(CC)=C3N=2)CCCC[C@H]1CCO |&1:25,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 |
| InChiKey | PIMQWRZWLQKKBJ-SFHVURJKSA-N |
| CID | 46926350 |
| Short Description | CDK inhibitor |
References
- LS Chen et al. Pim kinase inhibitor, SGI-1776, induces apoptosis in CLL lymphocytes. Blood, 2009, 114 (19), 4150-4157.
- SM Mumenthaler et al. Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. Mol. Cancer Ther. 2009, 8(10), 2882-2893.
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