Bulk Inquiry
XL 413 hydrochloride
- BMS 863233 hydrochloride
- Parent CAS: 1169558-38-6
- Soluble in water and DMSO
- MF: C14H12ClN3O2.HCl
- MW: 326.18
Description
XL 413 hydrochloride is a potent, selective and orally bioavailable CDC7 kinase inhibitor with an IC50 value of 3.4 nM. It inhibits tumor-cell proliferation and induces apoptosis in CDC7-overexpressing models by disrupting DNA replication initiation and S-phase progression.
CDC7 regulates origin firing and minichromosome maintenance (MCM) protein phosphorylation during DNA replication. XL 413 is valuable for studying cell-cycle dependency, replication-stress biology and CDC7-targeted oncology pharmacology.
Key Features
- Potent CDC7 kinase inhibitor
- IC50: 3.4 nM
- Selective over broad kinase panels
- Induces apoptosis in CDC7-dependent tumor-cell models
Applications
- CDC7 pharmacology
- DNA replication and S-phase studies
- Cell-cycle checkpoint research
- Oncology target-validation assays
More Information
| Parent CAS No. | 1169558-38-6 |
|---|---|
| Chemical Name | (S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride |
| MFCD | N.A. |
| Short Description | CDC7 inhibitor |
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