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AT 7519 mesylate
- Parent CAS: 844442-38-2
- Soluble in water
- MF: C16H17Cl2N5O2.CH4O3S
- MW: 478.35
Description
More Information
| Parent CAS No. | 844442-38-2 |
|---|---|
| Chemical Name | 4-(2,6-Dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide methanesulfonic acid |
| SMILES | C1C=CC(Cl)=C(C(NC2C(C(=O)NC3CCNCC3)=NNC=2)=O)C=1Cl.S(O)(C)(=O)=O |
| MFCD | MFCD17392576 |
| InChi | InChI=1S/C16H17Cl2N5O2.CH4O3S/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;1-5(2,3)4/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H3,(H,2,3,4) |
| InChiKey | UELIMKCXGLIYCY-UHFFFAOYSA-N |
| CID | 23657720 |
| Short Description | CDK inhibitor |
References
- L Sato et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition. Oncogene 2010, 29, 2325-2336.
- MS Squires et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol. Cancer Ther. 2010, 9(4), 920-928.
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