PF-06873600
- Ebvaciclib
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C20H27F2N5O4S
- MW: 471.52
Description
PF-06873600 (Ebvaciclib) is an orally bioavailable, potent, and selective inhibitor of CDK2, CDK4 and CDK6, with Ki values at 0.1 nM, 1.2 nM and 0.1 nM, respectively.
More Information
| Parent CAS No. | 2185857-97-8 |
|---|---|
| Chemical Name | 6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-(1-(methylsulfonyl)piperidin-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(NC2CCN(S(=O)(=O)C)CC2)N=C2N([C@H]3[C@@](O)(C)CCC3)C(=O)C(C(F)F)=CC2=CN=1 |&1:15,16,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1 |
| InChiKey | QIEKHLDZKRQLLN-FOIQADDNSA-N |
| CID | 134247638 |
| Short Description | CDK2/4/6 inhibitor |
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