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THZ1
- Soluble in DMSO
- MF: C31H28ClN7O2
- MW: 566.05
Description
THZ1 is a first covalent inhibitor of CDK7 (IC50 value of 3.2 nM) which employs a unique mechanism, combining ATP-site and allosteric covalent binding, as means of attaining potency and selectivity for CDK7. The dihydrochloride salt of THZ1 is also available as Axon 3561.
More Information
| Parent CAS No. | 1604810-83-4 |
|---|---|
| Chemical Name | (E)-N-(3-(5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide |
| MFCD | MFCD28167785 |
| Short Description | CDK7 inhibitor |
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