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THZ1 dihydrochloride

Axon 3561

Parent CAS: 1604810-83-4

Purity: 98%

Soluble in DMSO

MF: C31H28ClN7O2.2HCl
MW: 566.05

Description

THZ1 dihydrochloride is a first covalent inhibitor of CDK7 (IC50 value of 3.2 nM) which employs a unique mechanism, combining ATP-site and allosteric covalent binding, as means of attaining potency and selectivity for CDK7. The free base is also available as THZ1 (Axon 3560).

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

Parent CAS No.	1604810-83-4
Chemical Name	(E)-N-(3-(5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide dihydrochloride
MFCD	N.A.
Short Description	CDK7 inhibitor

THZ1 dihydrochloride CDK7 inhibitor THZ-1 dihydrochloride THZ 1 dihydrochloride CAS 1604810-83-4 CAS 2422107-17-1 Axon Medchem Axon 3560 Cyclin Dependent (CDK) CDK Inhibitor Enzymes T-cell acute lymphoblastic leukaemia T-ALL RUNX1 Supplier Vendor

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AXON ID	NAME	DESCRIPTION	FROM PRICE
1614	SNS 032	CDK inhibitor (2, 7 and 9 specific)	From $93.50
2998	Longdaysin	Potent CK1δ/CK1α inhibitor	From $137.50
3228	CDK inhibitor CR8	Potent CDK inhibitor (1, 2, 5, 7, and 9 specific)	From $143.00
3525	ETP-47799	Potent CDK8/CDK19 inhibitor	From $99.00
3560	THZ1	Covalent CDK7 inhibitor	From $66.00
3756	CT7001	Specific CDK7 inhibitor	From Inquiry

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THZ1 dihydrochloride

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