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PF-07104091
- Tagtociclib
- Optical Purity: 99% d.e.
- Soluble in DMSO
- MF: C19H28N6O4
- MW: 404.46
Description
PF-07104091 is a potent and selective CDK2 inhibitor with a Ki value of about 1 nM, highly selective against CDK1 (>100-fold), CDK4 and CDK6 (200 to 400-fold), CDK9 (170 fold), and GSK3B (>500-fold).
More Information
| Parent CAS No. | 2460249-19-6 |
|---|---|
| Chemical Name | (1R,3S)-3-(3-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | O(CC1=NN(C)C(C(NC2=NNC([C@H]3CC[C@@H](OC(=O)NC(C)C)C3)=C2)=O)=C1)C |&1:13,16,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H28N6O4/c1-11(2)20-19(27)29-14-6-5-12(7-14)15-9-17(23-22-15)21-18(26)16-8-13(10-28-4)24-25(16)3/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,20,27)(H2,21,22,23,26)/t12-,14+/m0/s1 |
| InChiKey | MTNBRBDFNSGQKB-GXTWGEPZSA-N |
| CID | 154616422 |
| Short Description | CDK2 inhibitor |
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