AZD4573
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C22H28ClN5O2
- MW: 429.94
Description
AZ4573 is a potent inhibitor of CDK9 with a biochemical IC50 of 10 fold) against all other CDKs and kinases. AZD4573 rapidly induces cell death in hematological tumor models (both in vitro and in vivo) through depletion of Mcl-1.
More Information
| Parent CAS No. | 2057509-72-3 |
|---|---|
| Chemical Name | (1S,3R)-3-acetamido-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)cyclohexanecarboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | [C@@H]1(C(=O)NC2N=CC(Cl)=C(C3C=NN4CC(C)(C)CC=34)C=2)C[C@H](NC(=O)C)CCC1 |&1:0,22,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 |
| InChiKey | AVIWDYSJSPOOAR-LSDHHAIUSA-N |
| CID | 124155204 |
| Short Description | CDK9 inhibitor |
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