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LY2857785
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C26H36N6O
- MW: 448.6
Description
LY2857785 is a highly potent and selective type I reversible and competitive ATP kinase CDK9 inhibitor with an IC50 value of 0.011 μM. LY2857785 significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines.
More Information
| Parent CAS No. | 1619903-54-6 |
|---|---|
| Chemical Name | trans-N1-(4-(3-Isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine |
| MFCD | MFCD28167812 |
| Short Description | CDK9 inhibitor |
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