KB-0742 dihydrochloride
Axon 3730
- Parent CAS: 2416873-83-9
- Optical Purity: 99% e.e.
- Soluble in water
- MF: C16H25N5.2HCl
- MW: 360.33
Description
KB-0742 is an orally bioavailable, potent and selective CDK9 inhibitor with an IC50 of 6 nM, highly selective against other CDKs (>60 fold). Demonstrates in vitro and in vivo anti-tumor activity.
More Information
| Parent CAS No. | 2416873-83-9 |
|---|---|
| Chemical Name | (1S,3S)-N1-(5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine dihydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1=C(N[C@H]2CC[C@H](N)C2)N2N=CC=C2N=C1C(CC)CC.Cl.Cl |&1:3,6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H25N5/c1-3-11(4-2)14-10-16(19-13-6-5-12(17)9-13)21-15(20-14)7-8-18-21/h7-8,10-13,19H,3-6,9,17H2,1-2H3/t12-,13-/m0/s1 |
| InChiKey | VYKCLMALANGCDF-STQMWFEESA-N |
| CID | 146502834 |
| Short Description | CDK9 inhibitor |
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