Voruciclib
- P1446A-05
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C22H19ClF3NO5
- MW: 469.84
Description
Voruciclib (P1446A-05) is an oral,potent and selective CDK inhibitor, blocking CDK9, the transcriptional regulator of MCL-1, with sub nanomolar potency, and suppressing MCL-1 expression in cell-based and xenograft models of DLBCL.
More Information
| Parent CAS No. | 1000023-04-0 |
|---|---|
| Chemical Name | 2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(O)C([C@]2([H])CCN(C)[C@]2(CO)[H])=C2OC(C3C=CC(C(F)(F)F)=CC=3Cl)=CC(=O)C2=C(O)C=1 |&1:3,9,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1 |
| InChiKey | MRPGRAKIAJJGMM-OCCSQVGLSA-N |
| CID | 67409219 |
| Short Description | CDK9 inhibitor |
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