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Aurora A inhibitor I
- Soluble in DMSO
- MF: C31H31ClFN7O2
- MW: 588.07
Description
Aurora A inhibitor I is a potent and selective Aurora A kinase inhibitor with reported IC50 value of 3.4 nM for Aurora A.
Aurora A regulates centrosome maturation, spindle assembly and mitotic progression. Aurora A inhibitor I is useful for studying Aurora A-selective mitotic defects and distinguishing Aurora A biology from Aurora B-dependent chromosome passenger functions.
Key Features
- Potent Aurora A kinase inhibitor
- Reported IC50: 3.4 nM for Aurora A
- High selectivity over Aurora B reported
- Tool compound for centrosome and spindle assembly studies
Applications
- Aurora A kinase assays
- Mitotic spindle and centrosome research
- Cancer cell-cycle inhibition studies
- Aurora kinase selectivity profiling
More Information
| Parent CAS No. | 1158838-45-9 |
|---|---|
| Chemical Name | N-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide |
| SMILES | N(C1C=CC(C(=O)NC2C=CC=CC=2Cl)=CC=1)C1C(=CN=C(NC2C=CC(CC(N3CCN(CC)CC3)=O)=CC=2)N=1)F |
| MFCD | MFCD16495816 |
| InChi | InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38) |
| InChiKey | AKSIZPIFQAYJGF-UHFFFAOYSA-N |
| CID | 44139710 |
| Short Description | Aurora A inhibitor |
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