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MLN0905
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H25F3N6S
- MW: 486.56
Description
MLN0905 is a potent, orally available and selective polo-like kinase 1 (PLK1) inhibitor.
PLK1 is a mitotic kinase required for centrosome maturation, spindle assembly, chromosome segregation and cytokinesis. MLN0905 is used to study PLK1-dependent mitotic progression and antiproliferative effects in oncology models.
Key Features
- Selective PLK1 inhibitor
- Orally available mitotic kinase research compound
- Blocks PLK1-dependent cell-cycle progression
- Relevant to oncology and antiproliferative pathway studies
Applications
- PLK1 kinase assays
- Mitosis and spindle checkpoint research
- Cancer cell-cycle and proliferation studies
- Pharmacodynamic biomarker and pathway inhibition profiling
More Information
| Parent CAS No. | 1228960-69-7 |
|---|---|
| Chemical Name | 2-(5-(3-(dimethylamino)propyl)-2-methylpyridin-3-ylamino)-9-(trifluoromethyl)-5H-benzo[b]pyrimido[4,5-d]azepine-6(7H)-thione |
| SMILES | N1C=C2CC(=S)NC3C=C(C(F)(F)F)C=CC=3C2=NC=1NC1=CC(CCCN(C)C)=CN=C1C |
| MFCD | MFCD22124494 |
| InChi | InChI=1S/C24H25F3N6S/c1-14-19(9-15(12-28-14)5-4-8-33(2)3)31-23-29-13-16-10-21(34)30-20-11-17(24(25,26)27)6-7-18(20)22(16)32-23/h6-7,9,11-13H,4-5,8,10H2,1-3H3,(H,30,34)(H,29,31,32) |
| InChiKey | CODBZFJPKJDNDT-UHFFFAOYSA-N |
| CID | 46235922 |
| Short Description | PLK1 inhibitor |
References
- MO Duffey et al. Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905). J. Med. Chem. 2012, 55 (1), 197-208.
- JQ Shi et al. MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma. Mol. Cancer Ther. 2012, 11(9), 2045-2053.
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