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Aurora A inhibitor II
- Soluble in DMSO
- MF: C31H29ClFN7O3
- MW: 602.06
Description
Aurora A inhibitor II is a potent and selective Aurora A kinase inhibitor with reported IC50 value of 4.3 nM for Aurora A.
Aurora A coordinates centrosome maturation and spindle assembly during mitosis. Aurora A inhibitor II is useful for studying Aurora A-dependent mitotic phenotypes and for comparing Aurora A-selective effects against Aurora B-mediated chromosomal passenger functions.
Key Features
- Potent Aurora A kinase inhibitor
- Reported IC50: 4.3 nM for Aurora A
- High selectivity over Aurora B reported
- Useful tool for mitotic spindle and centrosome biology
Applications
- Aurora A kinase assays
- Mitosis and spindle assembly research
- Cancer cell-cycle inhibition studies
- Aurora kinase selectivity profiling
More Information
| Parent CAS No. | 1158838-43-7 |
|---|---|
| Chemical Name | 4-(2-(4-(2-(4-acetylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)-N-(2-chlorophenyl)benzamide |
| SMILES | N(C1C=CC(C(=O)NC2C=CC=CC=2Cl)=CC=1)C1C(=CN=C(NC2C=CC(CC(N3CCN(C(=O)C)CC3)=O)=CC=2)N=1)F |
| MFCD | N.A. |
| InChi | InChI=1S/C31H29ClFN7O3/c1-20(41)39-14-16-40(17-15-39)28(42)18-21-6-10-24(11-7-21)36-31-34-19-26(33)29(38-31)35-23-12-8-22(9-13-23)30(43)37-27-5-3-2-4-25(27)32/h2-13,19H,14-18H2,1H3,(H,37,43)(H2,34,35,36,38) |
| InChiKey | GAAHSFKFIMENOG-UHFFFAOYSA-N |
| CID | 42628077 |
| Short Description | Aurora A inhibitor |
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