The Aurora kinase family (EC is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis, essential for accurate and equal segregation of genomic material from parent to daughter cells. As a result, they play a central role in cell cycle regulation[1]. Three related kinases known as Aurora-A, Aurora-B, and Aurora-C have been characterized over the years. Despite significant sequence homology, the localization and functions of these kinases are largely distinct from one another. Given the association of Aurora over-expression and tumorigenesis, these kinases have been targeted for cancer therapy, and a new class of drugs known as Aurora kinase inhibitors has been developed[2],[3].

[1] Mitotic kinases as regulators of cell division and its checkpoints. E.A. Nigg. Nat. Rev. Mol. Cell Biol. 2001, 2, 21–32.
[2] Aurora kinases. V.M. Bolanos-Garcia. Int. J. Biochem. & Cell Biol. 2005, 37, 1572–1577.
[3] Aurora Kinases: New Targets for Cancer Therapy. R.D. Carvajal, A. Tse, G.K. Schwartz. Clin. Cancer Res. 2006, 12, 6869.

17 Item(s)

per page
Axon ID Name Description From price
3408 AKI603 Inhibitor of Aurora A kinase €145.00
1783 AMG 900 Aurora inhibitor (non-specific) €110.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
1597 Aurora A inhibitor I Aurora A inhibitor €125.00
1630 Aurora A inhibitor II Aurora A inhibitor €125.00
1580 AZD1152-HQPA Aurora B inhibitor €70.00
1836 CCT 137690 Aurora inhibitor (non-specific) €115.00
4073 CYC-116 Aurora kinases A & B and VEGFR2 inhibitor Inquire
3920 GSK1070916 Potent, selective and ATP competitive inhibitor of Aurora B and C kinases €110.00
2096 Hesperadin Reversible and ATP-competitive inhibitor of Aurora B €95.00
3758 LY-3295668 Orally available, potent and highly selective Aurora A kinase (AurA) inhibitor Inquire
1961 MK 5108 Inhibitor of Aurora A kinase €110.00
2003 MLN8237 Second generation selective Aurora A inhibitor €90.00
2023 PF 03814735 ATP-competitive inhibitor of aurora kinase A and B €120.00
2906 SNS 314 mesylate Potent and selective Aurora inhibitor (non-specific) €90.00
1540 VX 680 Aurora inhibitor (non-specific) €60.00
1541 ZM 447439 Aurora B inhibitor €85.00

17 Item(s)

per page
Please wait...