Aurora

The Aurora kinase family (EC 2.7.11.1) is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis, essential for accurate and equal segregation of genomic material from parent to daughter cells. As a result, they play a central role in cell cycle regulation[1]. Three related kinases known as Aurora-A, Aurora-B, and Aurora-C have been characterized over the years. Despite significant sequence homology, the localization and functions of these kinases are largely distinct from one another. Given the association of Aurora over-expression and tumorigenesis, these kinases have been targeted for cancer therapy, and a new class of drugs known as Aurora kinase inhibitors has been developed[2],[3].


[1] Mitotic kinases as regulators of cell division and its checkpoints. E.A. Nigg. Nat. Rev. Mol. Cell Biol. 2001, 2, 21–32.
[2] Aurora kinases. V.M. Bolanos-Garcia. Int. J. Biochem. & Cell Biol. 2005, 37, 1572–1577.
[3] Aurora Kinases: New Targets for Cancer Therapy. R.D. Carvajal, A. Tse, G.K. Schwartz. Clin. Cancer Res. 2006, 12, 6869.

12 Item(s)

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Axon ID Name Description From price
1783 AMG 900 Aurora inhibitor (non-specific) €115.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
1597 Aurora A inhibitor I Aurora A inhibitor €125.00
1630 Aurora A inhibitor II Aurora A inhibitor €125.00
1580 AZD 1152-HQPA Aurora B inhibitor €85.00
1836 CCT 137690 Aurora inhibitor (non-specific) €115.00
2096 Hesperadin Reversible and ATP-competitive inhibitor of Aurora B €95.00
1961 MK 5108 Inhibitor of Aurora A kinase €110.00
2003 MLN 8237 Second generation selective Aurora A inhibitor €105.00
2023 PF 03814735 ATP-competitive inhibitor of aurora kinase A and B €120.00
1540 VX 680 Aurora inhibitor (non-specific) €60.00
1541 ZM 447439 Aurora B inhibitor €85.00

12 Item(s)

per page
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