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AKI603
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C19H23N9O2
- MW: 409.45
Description
AKI603 significantly inhibited Aurora A kinase (IC50 value of 12.3 nM) and induced cell-cycle arrest. In addition, the intragastric administration of AKI603 reduced xenograft tumor growth.
More Information
| Parent CAS No. | 1432515-73-5 |
|---|---|
| Chemical Name | N4-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-N2-(4-nitrophenyl)pyrimidine-2,4-diamine |
| SMILES | C1C(NC2=NNC(C)=C2)=NC(NC2C=CC([N+]([O-])=O)=CC=2)=NC=1N1CCN(C)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H23N9O2/c1-13-11-17(25-24-13)21-16-12-18(27-9-7-26(2)8-10-27)23-19(22-16)20-14-3-5-15(6-4-14)28(29)30/h3-6,11-12H,7-10H2,1-2H3,(H3,20,21,22,23,24,25) |
| InChiKey | UNKOUVAYOLLXER-UHFFFAOYSA-N |
| CID | 72194397 |
| Short Description | Aurora A Inhibitor |
References
- Y Luo et al. Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors. Eur J Med Chem. 2014 May 6;78:65-71.
- FM Zheng et al. A novel small molecule aurora kinase inhibitor attenuates breast tumor-initiating cells and overcomes drug resistance. Mol Cancer Ther. 2014 Aug;13(8):1991-2003.
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