XL-228
- Soluble in DMSO
- MF: C22H31N9O
- MW: 437.54
Description
More Information
| Parent CAS No. | 898280-07-4 |
|---|---|
| Chemical Name | N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C(NC2=NNC(C3CC3)=C2)=NC(NCC2=CC(C(C)C)=NO2)=NC=1N1CCN(C)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H31N9O/c1-14(2)17-10-16(32-29-17)13-23-22-25-19(24-20-11-18(27-28-20)15-4-5-15)12-21(26-22)31-8-6-30(3)7-9-31/h10-12,14-15H,4-9,13H2,1-3H3,(H3,23,24,25,26,27,28) |
| InChiKey | ALKJNCZNEOTEMP-UHFFFAOYSA-N |
| CID | 59757974 |
| Short Description | IGF1R, AURORA kinases, FGFR1-3, ABL, ALK, and SRC inhibitor |
References
- J Cortes et al. Preliminary Clinical Activity in a Phase I Trial of the BCR-ABL/IGF- 1R/Aurora Kinase Inhibitor XL228 in Patients with Ph++ Leukemias with Either Failure to Multiple TKI Therapies or with T315I Mutation. Blood 2008 112:3232.
- O Douglas et al. Abstract C192: Characterization of the target profile of XL228, a multi‐targeted protein kinase inhibitor in phase 1 clinical development. Mol Cancer Ther 2009;8(12 Suppl):C192.
- N Shah et al. Targeting Drug-Resistant CML and Ph+-ALL with the Spectrum Selective Protein Kinase Inhibitor XL228. Blood 2007 110:474.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 4489 | I-OMe-Tyrphostin AG 538 |
From $154.00 |
| 1136 | SU 6656 |
From $132.00 |
| 1392 | Dasatinib |
From $99.00 |
| 1407 | SKI 606 |
From $82.50 |
| 1416 | NVP-TAE684 |
From $55.00 |
| 1419 | AB 1010 |
From $77.00 |
| 1456 | AZD0530 difumarate |
From $115.50 |
| 1540 | VX 680 |
From $66.00 |
| 1541 | ZM 447439 |
From $93.50 |
| 1580 | AZD1152-HQPA |
From $77.00 |
| 1597 | Aurora A inhibitor I |
From $137.50 |
| 1630 | Aurora A inhibitor II |
From $137.50 |
| 1660 | Crizotinib |
From $88.00 |
| 1667 | SU 5402 |
From $66.00 |
| 1673 | PD173074 |
From $82.50 |
| 1698 | A 770041 |
From $154.00 |
| 1702 | OSI 906 |
From $66.00 |
| 1763 | CoPo 22 |
From $132.00 |
| 1775 | NVP-BGJ398 |
From $88.00 |
| 1836 | CCT 137690 |
From $126.50 |
| 1891 | SU 6668 |
From $110.00 |
| 1892 | 1-NM-PP1 |
From $104.50 |
| 1917 | AZD4547 |
From $93.50 |
| 1941 | MLR 1023 |
From $104.50 |
