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CoPo 22
Axon 1763
CAS:
606101-83-1
Purity:
99%
- Soluble in DMSO
- MF: C22H22N4O2
- MW: 374.44
Description
Corrector and potentiator (Co-Po) for ∆F508-cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel function in cystic fibrosis, with low micromolar EC50
More Information
| Parent CAS No. | 606101-83-1 |
|---|---|
| Chemical Name | N-(2-(3-cyano-5,7-dimethylquinolin-2-ylamino)ethyl)-3-methoxybenzamide |
| SMILES | C(NCCNC1C(C#N)=CC2C(N=1)=CC(C)=CC=2C)(=O)C1=CC=CC(OC)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H22N4O2/c1-14-9-15(2)19-12-17(13-23)21(26-20(19)10-14)24-7-8-25-22(27)16-5-4-6-18(11-16)28-3/h4-6,9-12H,7-8H2,1-3H3,(H,24,26)(H,25,27) |
| InChiKey | TZGJSWWPNARXQC-UHFFFAOYSA-N |
| CID | 3224090 |
| Short Description | CFTR Co-Po |
References
- PW Phuan et al. Cyanoquinolines with Independent Corrector and Potentiator Activities Restore ∆F508-CFTR Chloride Channel Function in Cystic Fibrosis. Mol. Pharmacol. 2011, 80(4), 683-693.
- AS Verkman et al. CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis. Curr. Pharm. Des. 2006; 12(18), 2235-2247.
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