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VX 661
- Tezacaftor
Axon 2169
CAS:
1152311-62-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C26H27F3N2O6
- MW: 520.5
Description
Corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), hypothesized to restore F508del mutation processing and plasma membrane localization of CFTR protein, thereby effectively increasing functional surface CFTR ion channels. VX 661 is the second CFTR corrector in line with VX 809 (first), and VX 983 (third), and is believed to help CFTR protein reach the cell surface.
Tested in phase 2 to evaluate safety, efficacy, pharmacokinetics, and pharmacodynamics in subjects with cystic fibrosis suffering from the F508del-CFTR mutation.
More Information
| Parent CAS No. | 1152311-62-0 |
|---|---|
| Chemical Name | (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| SMILES | C1(C2=CC=C3OC(F)(F)OC3=C2)(C(NC2C(F)=CC3=C(C=2)C=C(C(C)(CO)C)N3C[C@@H](O)CO)=O)CC1 |&1:30,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C26H27F3N2O6/c1-24(2,13-33)22-8-14-7-18(17(27)10-19(14)31(22)11-16(34)12-32)30-23(35)25(5-6-25)15-3-4-20-21(9-15)37-26(28,29)36-20/h3-4,7-10,16,32-34H,5-6,11-13H2,1-2H3,(H,30,35)/t16-/m1/s1 |
| InChiKey | MJUVRTYWUMPBTR-MRXNPFEDSA-N |
| CID | 46199646 |
| Short Description | CFTR corrector |
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