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Lumacaftor
- VX-809
Axon 3234
CAS:
936727-05-8
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C24H18F2N2O5
- MW: 452.41
Description
Lumacaftor is an efficacious and selective CFTR corrector. Lumacaftor was orally bioavailable in rats and achieved in vivo plasma levels significantly above concentrations required for in vitro efficacy.
More Information
| Parent CAS No. | 936727-05-8 |
|---|---|
| Chemical Name | 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| SMILES | C12OC(F)(F)OC=1C=C(C1(CC1)C(NC1C=CC(C)=C(C3C=C(C(O)=O)C=CC=3)N=1)=O)C=C2 |
| MFCD | MFCD16659051 |
| InChi | InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31) |
| InChiKey | UFSKUSARDNFIRC-UHFFFAOYSA-N |
| CID | 16678941 |
| Short Description | CFTR corrector |
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