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Ataluren
- PTC124
Axon 4049
CAS:
775304-57-9
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C15H9FN2O3
- MW: 284.24
Description
Ataluren is an orally bioavailable suppressor of the human CFTR-G542X nonsense allele.
More Information
| Parent CAS No. | 775304-57-9 |
|---|---|
| Chemical Name | 3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid |
| MFCD | MFCD09864996 |
| Short Description | CFTR-G542X suppressor |
References
- EM Welch et al. PTC124 targets genetic disorders caused by nonsense mutations. Nature. 2007 May 3;447(7140):87-91.
- M Du et al. PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2064-9.
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