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Eact
Axon 2576
CAS:
461000-66-8
Purity:
100%
- Soluble in DMSO
- MF: C22H24N2O5S
- MW: 428.5
Description
Eact is a small molecule activator of TMEM16A (also called ANO1). It strongly triggers the TMEM16A chloride channel without raising cellular calcium levels. By prompting fluid secretion in airways and glands, it holds therapeutic potential for multiple medical conditions.
TMEM16A pharmacology plays a vital role in researching tissue scarring and cystic fibrosis. Scientists use the activator Eact to study this specific chloride channel across laboratory, cellular, and animal models.
- Selectively turns on TMEM16A (ANO1), a calcium-activated chloride channel
- Functions directly without raising internal cellular calcium
- Boosts moisture release from airways and glands
- Targets cystic fibrosis, dry mouth, and gut disorders
Applications
- TMEM16A pharmacology and target-validation studies
- TMEM16A pathway mechanism profiling and signaling assays
- Disease-model research related to fibrosis, cystic fibrosis
- Dryness syndrome studies and gut motility investigation
More Information
| Parent CAS No. | 461000-66-8 |
|---|---|
| Chemical Name | 3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide |
| SMILES | C(N(CCOC)C1=NC(C2=CC=CC=C2)=CS1)(=O)C1=CC(OC)=C(OC)C(OC)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3 |
| InChiKey | ZUXNHFFVQWADJL-UHFFFAOYSA-N |
| CID | 3173542 |
| Short Description | TMEM16A activator |
Eact
TMEM16A/ANO1 chloride-channel activator
Chloride
ANO1
CaCC
TMEM16A/ANO1 chloride-channel
calcium activated chloride channel
Ion Channel
Activator
TMEM16A pharmacology
TMEM16A mechanism and signaling assays
fibrosis and cystic fibrosis
Dryness syndrome studies and gut motility investigation
fibrosis
receptor selectivity
signal transduction
CAS 461000-66-8
Axon Medchem
Axon 2576
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