LY-3295668
- AK-01
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C24H26ClF2N5O2
- MW: 489.95
Description
LY3295668 is an orally available, potent and highly selective Aurora A kinase (AurA) inhibitor with Ki of 0.8 nM, and H446 AurA auto-P IC50 of 0.6 nM, highly selective (>1000 fold) over Aurora B. LY3295668 is cytotoxic to RB1 mutant cancer cells (NCI-H446 cell IC50 = 0.752 uM), and achieves durable regression of RB1mut tumor xenografts.
More Information
| Parent CAS No. | 1919888-06-4 |
|---|---|
| Chemical Name | (2R,4R)-1-(3-Chloro-2-fluorobenzyl)-4-((3-fluoro-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)-2-methylpiperidine-4-carboxylic acid |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(CN2[C@H](C)C[C@@](C(=O)O)(CC3C(F)=CC=C(NC4=NNC(C)=C4)N=3)CC2)C=CC=C(Cl)C=1F |&1:3,6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H26ClF2N5O2/c1-14-10-21(31-30-14)29-20-7-6-18(26)19(28-20)12-24(23(33)34)8-9-32(15(2)11-24)13-16-4-3-5-17(25)22(16)27/h3-7,10,15H,8-9,11-13H2,1-2H3,(H,33,34)(H2,28,29,30,31)/t15-,24-/m1/s1 |
| InChiKey | YQQZZYYQTCPEAS-OYLFLEFRSA-N |
| CID | 121333423 |
| Short Description | Aurora A inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1540 | VX 680 |
From $66.00 |
| 1541 | ZM 447439 |
From $93.50 |
| 1580 | AZD1152-HQPA |
From $77.00 |
| 1597 | Aurora A inhibitor I |
From $137.50 |
| 1630 | Aurora A inhibitor II |
From $137.50 |
| 1783 | AMG 900 |
From $121.00 |
| 1836 | CCT 137690 |
From $126.50 |
| 1961 | MK 5108 |
From $121.00 |
| 2003 | MLN8237 |
From $99.00 |
| 2023 | PF 03814735 |
From $132.00 |
| 2096 | Hesperadin |
From $104.50 |
| 2219 | AT 9283 |
From $99.00 |
| 2906 | SNS 314 mesylate |
From $99.00 |
| 3408 | AKI603 |
From $159.50 |
| 3920 | GSK1070916 |
From $121.00 |
| 3973 | XL-228 |
From Inquiry |
| 4073 | CYC-116 |
From Inquiry |
