Bulk Inquiry
MLN8237
- Alisertib
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C27H20ClFN4O4
- MW: 518.92
Description
More Information
| Parent CAS No. | 1028486-01-2 |
|---|---|
| Chemical Name | 4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)-2-methoxybenzoic acid |
| SMILES | C(O)(=O)C1=CC=C(NC2=NC=C3C(=N2)C2=CC=C(Cl)C=C2C(C2=C(OC)C=CC=C2F)=NC3)C=C1OC |
| MFCD | MFCD16621243 |
| InChi | InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33) |
| InChiKey | ZLHFILGSQDJULK-UHFFFAOYSA-N |
| CID | 24771867 |
| Short Description | Aurora A inhibitor |
References
- DA Sloane et al. Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237. ACS Chem. Biol. 2010, 5(6), 563-576.
- G Görgün et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood. 2010, 115(25), 5202-5213.
- M Tomita, N Mori. Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cells in vitro. Cancer Sci. 2010, 101(5), 1204-1211.
- MG Manfredi et al. Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays. Clin. Cancer Res. 2011, 17(24), 7614-7624.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1129 | BI 2536 |
From $99.00 |
| 1131 | GW 843682X |
From $93.50 |
| 1473 | BI 6727 |
From $99.00 |
| 1530 | RO 3306 |
From $88.00 |
| 1538 | JNJ 26854165 |
From $115.50 |
| 1540 | VX 680 |
From $66.00 |
| 1541 | ZM 447439 |
From $93.50 |
| 1580 | AZD1152-HQPA |
From $77.00 |
| 1585 | Nutlin-3 |
From $104.50 |
| 1586 | JNJ 26854165 dihydrochloride |
From $115.50 |
| 1597 | Aurora A inhibitor I |
From $137.50 |
| 1625 | GSK579289A |
From $121.00 |
| 1626 | GSK 461364 analogue II |
From $143.00 |
| 1630 | Aurora A inhibitor II |
From $137.50 |
| 1643 | HLI 373 |
From $143.00 |
| 1688 | GSK 461364 |
From $115.50 |
| 1783 | AMG 900 |
From $121.00 |
| 1836 | CCT 137690 |
From $126.50 |
| 1880 | Nutlin-3a |
From $104.50 |
| 1881 | Nutlin-3b |
From $99.00 |
| 1904 | SMER 3 |
From $99.00 |
| 1910 | MLN0905 |
From $104.50 |
| 1953 | PRT 4165 |
From $77.00 |
| 1961 | MK 5108 |
From $121.00 |
