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MK 5108
- VX 689
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C22H21ClFN3O3S
- MW: 461.94
Description
MK 5108 (VX689) is a highly potent and selective Aurora A kinase inhibitor. It disrupts Aurora A-dependent mitotic regulation and has been reported to suppress tumor cell growth in vitro and in vivo.
Aurora A regulates centrosome maturation, spindle assembly and mitotic progression. MK 5108 is pharmacologically relevant for studying mitotic kinase inhibition, cancer cell-cycle arrest and combination strategies with antimitotic agents such as docetaxel.
Key Features
- Selective Aurora A kinase inhibitor
- Modulates mitotic spindle and centrosome regulation
- Reported antitumor activity in cellular and in vivo models
- Useful for combination studies with antimitotic chemotherapy
Applications
- Aurora A kinase assays
- Mitotic checkpoint and cell-cycle studies
- Oncology pharmacology models
- Combination therapy research
More Information
| Parent CAS No. | 1010085-13-8 |
|---|---|
| Chemical Name | (1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexanecarboxylic acid |
| SMILES | [C@]1(CC2=NC(NC3=NC=CS3)=CC=C2)(C(O)=O)CC[C@@H](OC2=CC=CC(Cl)=C2F)CC1 |&1:0,19,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27) |
| InChiKey | LCVIRAZGMYMNNT-UHFFFAOYSA-N |
| CID | 24748204 |
| Short Description | Aurora A Inhibitor |
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