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AT 9283
- Soluble in water and DMSO
- MF: C19H23N7O2
- MW: 381.43
Description
More Information
| Parent CAS No. | 896466-04-9 |
|---|---|
| Chemical Name | 1-cyclopropyl-3-(3-(6-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea |
| SMILES | N(C1CC1)C(NC1=CNN=C1C1NC2=CC(CN3CCOCC3)=CC=C2N=1)=O |
| MFCD | MFCD12031513 |
| InChi | InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27) |
| InChiKey | LOLPPWBBNUVNQZ-UHFFFAOYSA-N |
| CID | 135398495 |
| Short Description | Aurora/JAK inhibitor |
References
- W. Qi et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int. J. Cancer. 2012, 130, 2997-3005.
- R. Tanaka et al. Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells. Blood. 2010, 116, 2089-2095.
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