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AT 9283

Axon 2219
CAS:  896466-04-9
Purity:  99%
  • Soluble in water and DMSO
  • MF:  C19H23N7O2
  • MW:  381.43

Description

A multitargeted kinase inhibitor with high affinity for Aurora A and B, JAK2/3, and BCR-Abl(T315I) (IC50 values 3, 3, 1.2, 1.1, and 4 nM respectively). AT 9283 has a potent anti-proliferative activity in a panel of Ba/F3 and human cell lines expressing the BCR-Abl fusion protein or its mutant forms including T315I, and it has the potential to significantly benefit patients with imatinib-resistant CML or with Ph+ ALL.

More Information

Parent CAS No. 896466-04-9
Chemical Name 1-cyclopropyl-3-(3-(6-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
SMILES N(C1CC1)C(NC1=CNN=C1C1NC2=CC(CN3CCOCC3)=CC=C2N=1)=O
MFCD MFCD12031513
InChi InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27)
InChiKey LOLPPWBBNUVNQZ-UHFFFAOYSA-N
CID 135398495
Short Description Aurora/JAK inhibitor

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