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AZ 960
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C18H16F2N6
- MW: 354.36
Description
More Information
| Parent CAS No. | 905586-69-8 |
|---|---|
| Chemical Name | (S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile |
| SMILES | C1(N[C@H](C2=CC=C(F)C=C2)C)=NC(NC2C=C(C)NN=2)=C(F)C=C1C#N |&1:2,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H16F2N6/c1-10-7-16(26-25-10)23-18-15(20)8-13(9-21)17(24-18)22-11(2)12-3-5-14(19)6-4-12/h3-8,11H,1-2H3,(H3,22,23,24,25,26)/t11-/m0/s1 |
| InChiKey | SUNXHXDJOIXABJ-NSHDSACASA-N |
| CID | 25099184 |
| Short Description | JAK2 inhibitor |
References
- JM Gozgit et al. Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2. J. Biol. Chem. 2008, 283(47), 32334-32343.
- J Yang et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010, 9(12), 3386-3395.
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