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Napabucasin
- BBI 608 - FNQ
- Soluble in DMSO
- MF: C14H8O4
- MW: 240.21
Description
Oral first-in-class cancer stemness (CSCs) inhibitor that works by targeting STAT3. Napabucasin is a naturally occurring drug with enhanced toxicity versus glucose-starved tumor cells, and found to induce Mcl-1 cleavage and sustained phosphorylation of c-Jun-N-terminal kinase. Effectively blocks cancer relapse and metastasis in xenografted human cancers.
More Information
| Parent CAS No. | 83280-65-3 |
|---|---|
| Chemical Name | 2-acetylbenzo[f][1]benzofuran-4,9-dione |
| SMILES | O1C(C(C)=O)=CC2C(=O)C3=C(C(=O)C1=2)C=CC=C3 |
| MFCD | N.A. |
| InChi | InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3 |
| InChiKey | DPHUWDIXHNQOSY-UHFFFAOYSA-N |
| CID | 10331844 |
| Short Description | STAT3 inhibitor |
References
- V. Kuete et al. Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants. PLoS One. 2011;6(8):e21762.
- M. Rieber et al. Mcl-1 cleavage and sustained phosphorylation of c-Jun-N-terminal kinase mediate melanoma apoptosis induced by 2-acetyl furanonaphthoquinone: roles of Bcl-2 and p53. Cancer Biol Ther. 2008 Aug;7(8):1206-11.
- Y. Li et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44.
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