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BP-1-102
Axon 3786
CAS:
1334493-07-0
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C29H27F5N2O6S
- MW: 626.59
Description
BP-1-102 is an orally bioavailable inhibitor of transcription factor Stat3 with an IC50 value of 6.8 μM. BP-1-102 binds Stat3 with an affinity (KD) of 504 nM, blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM, and selectively inhibits growth, survival, migration, and invasion of Stat3-dependent tumor cells.
More Information
| Parent CAS No. | 1334493-07-0 |
|---|---|
| Chemical Name | 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid |
| SMILES | C1CCCC(C2C=CC(CN(C3C=CC(C(=O)O)=C(O)C=3)C(CN(C)S(=O)(=O)C3C(F)=C(F)C(F)=C(F)C=3F)=O)=CC=2)C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C29H27F5N2O6S/c1-35(43(41,42)28-26(33)24(31)23(30)25(32)27(28)34)15-22(38)36(19-11-12-20(29(39)40)21(37)13-19)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h7-13,17,37H,2-6,14-15H2,1H3,(H,39,40) |
| InChiKey | WNVSFFVDMUSXSX-UHFFFAOYSA-N |
| CID | 53388144 |
| Short Description | STAT3 inhibitor |
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