Bulk Inquiry
Alantolactone
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C15H20O2
- MW: 232.32
Description
Alantolactone is a STAT3 inhibitor which completely suppressed inducible and constitutively activated STAT3 and blocked the nuclear translocation and the DNA-binding activity of STAT3 in MDA-MB-231 cells. Also, Alantolactone inhibited activity of NLRP3 inflammasomes by directly targeting the NACHT domain of NLRP3.
More Information
| Parent CAS No. | 546-43-0 |
|---|---|
| Chemical Name | (3aR,5S,8aR,9aR)-5,8a-Dimethyl-3-methylene-3,3a,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(5H)-one |
| SMILES | C1C[C@]2(C)C[C@@]3([H])OC(=O)C(=C)[C@@]3([H])C=C2[C@@H](C)C1 |&1:2,5,12,16,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1 |
| InChiKey | PXOYOCNNSUAQNS-AGNJHWRGSA-N |
| CID | 72724 |
| Short Description | STAT3/NLRP3 inhibitor |
References
- J Chun et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357(1):393-403.
- W Li et al. Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice. Br J Pharmacol. 2023 Jan 20.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 2313 | S3I 201 |
From $99.00 |
| 2314 | Stattic |
From $55.00 |
| 2316 | WP 1066 |
From $104.50 |
| 2488 | Piperlongumine |
From $71.50 |
| 2489 | Brassinin |
From $82.50 |
| 2517 | Napabucasin |
From $115.50 |
| 3270 | Lj-1-60 |
From $99.00 |
| 3475 | Dapansutrile |
From $77.00 |
| 3786 | BP-1-102 |
From $99.00 |
| 3877 | BMS-986299 |
From $154.00 |
