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NVP-BSK805
- BSK 805
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C27H28F2N6O
- MW: 490.55
Description
NVP-BSK805 is a potent, selective and orally bioavailable JAK2 inhibitor (IC50 value of 7.3 nM) with very good solubility and cellular potency. Moreover, NVP-BSK805 potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.
More Information
| Parent CAS No. | 1092499-93-8 |
|---|---|
| Chemical Name | 4-(2,6-Difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine |
| SMILES | C1C(C2C=C(F)C(CN3CCOCC3)=C(F)C=2)=C2N=C(C3C=NN(C4CCNCC4)C=3)C=NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C27H28F2N6O/c28-23-12-18(13-24(29)22(23)17-34-8-10-36-11-9-34)21-2-1-3-25-27(21)33-26(15-31-25)19-14-32-35(16-19)20-4-6-30-7-5-20/h1-3,12-16,20,30H,4-11,17H2 |
| InChiKey | IBPVXAOOVUAOKJ-UHFFFAOYSA-N |
| CID | 46398810 |
| Short Description | JAK2 inhibitor |
References
- C Pissot-Soldermann et al. Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2609-13.
- F Baffert et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55.
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