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Momelotinib hydrochloride
- CYT387 hydrochloride
- Parent CAS: 1056634-68-4
- Soluble in DMSO
- MF: C23H22N6O2.HCl
- MW: 450.92
Description
Selective and ATP-competitive Janus Kinase JAK1/JAK2 inhibitor, with IC50 to be 11 and 18 nM for JAK1 and JAK2 respectively and far less activity against other kinases, including JAK3 (IC50=155 nM). The free base, Momelotinib (Axon 1681) is also available.
More Information
| Parent CAS No. | 1056634-68-4 |
|---|---|
| Chemical Name | N-(Cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride |
| MFCD | N.A. |
| Short Description | JAK1/2 inhibitor |
References
- A Pardanan et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia 2009, 23, 1441–1445.
- JW Tyner et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood 2010, 115(25), 5232-5240.
- S Verstovsek. Therapeutic potential of JAK2 inhibitors. Hematology Am Soc Hematol Educ Program. 2009, 636-642.
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