Bulk Inquiry
JAK inhibitor I
- Pyridone 6
- Soluble in DMSO and EtOH
- MF: C18H16FN3O
- MW: 309.34
Description
JAK inhibitor I is a potent pan-JAK inhibitor with IC50 values of 15, 1, 1 and 5 nM for murine Jak1, Tyk2, Jak2 and Jak3, respectively. JAK inhibitor I also blocks IL2 and IL4 dependent proliferation of CTLL cells and inhibits the phosphorylation of STAT5.
More Information
| Parent CAS No. | 457081-03-7 |
|---|---|
| Chemical Name | 4-tert-Butyl-15-fluoro-3,5,10-triazatetracyclo[11.4.0.0²,⁶.0⁷,¹²]heptadeca-1(17),2(6),3,7(12),8,13,15-heptaen-11-one |
| SMILES | C12C3=CC(F)=CC=C3C3N=C(C(C)(C)C)NC=3C=1C=CNC2=O |
| MFCD | MFCD17019334 |
| InChi | InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22) |
| InChiKey | VNDWQCSOSCCWIP-UHFFFAOYSA-N |
| CID | 5494425 |
| Short Description | JAK inhibitor |
References
- JE Thompson et al. Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23.
- R Nakagawa et al. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J Immunol. 2011 Nov 1;187(9):4611-20.
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