Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

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Axon ID Name Description From price
2537 1,5-Isoquinolinediol PARP1 inhibitor and neuroprotective agent €50.00
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
2141 ABT 199 Potent, orally bioavailable BCL-2-selective inhibitor €135.00
1593 ABT 888 PARP inhibitor €65.00
1529 AG 014699 PARP1 inhibitor €85.00
2269 AK 1 Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 €90.00
2270 AK 7 Potent, brain-permeable and selective inhibitor of SIRT2 €90.00
2540 Akt Inhibitor VIII Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR) €125.00
2639 AMG 232 Potent, selective, and orally bioavailable MDM2-p53 inhibitor €115.00
1783 AMG 900 Aurora inhibitor (non-specific) €115.00
1496 Aminobenzamide, 3- Competitive small molecule inhibitor of PARP €45.00
2368 Amuvatinib RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met €105.00
2251 Apoptozole Inhibitor of ATPase activity of Hsc70 and Hsp70 €95.00
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy  Recently added €90.00
1985 AT 406 Antagonist of Inhibitor of apoptosis proteins (IAPs) €145.00

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