Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

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Axon ID Name Description From price
1826 DBeQ Inhibitor of p97 ATPase €90.00
2574 Defactinib Orally available second generation inhibitor of FAK and PYK2 €95.00
2496 Dimethylcelecoxib, 2,5- Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity €75.00
2439 Dimethylenastron Specific potent and cell-permeable inhibitor of Eg5 (KSP) €105.00
1268 DR 2313 PARP inhibitor €90.00
2351 EHop 016 Rac GTPase inhibitor specific for Rac1 and Rac3 €85.00
2568 EML 425 Potent reversible dual inhibitor of CBP and p300 (HAT/KAT3) €95.00
2831 EPZ 015666 Potent, selective and orally available inhibitor of PRMT5 €125.00
2227 EPZ 6438 Inhibitor of Histone Lysine Methyltransferase EZH2 €105.00
1825 Erastin VDAC2 modulator €95.00
2384 FDI 6 Inhibitor of the Forkhead box protein M1 (FOXM1) €99.00
2293 Ferrostatin 1 Potent inhibitor of erastin-induced ferroptosis €85.00
2686 FH535 Dual inhibitor of PPAR and Wnt/β-catenin signaling €75.00
2706 FH535 sodium salt Dual inhibitor of PPAR and Wnt/β-catenin signaling €80.00
2355 FPH 2 Proliferation inducer of mature human primary hepatocytes €110.00

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