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Myoseverin
- Soluble in DMSO
- MF: C24H28N6O2
- MW: 432.52
Description
Myoseverin is a microtubule-binding compound and reversible tubulin polymerization inhibitor.
Myoseverin disrupts microtubule organization and has been used to induce reversible myotube fragmentation, making it useful for skeletal muscle plasticity, cytoskeletal remodeling and angiogenesis-related research.
Key Features
- Reversible tubulin polymerization inhibitor
- Binds microtubules and disrupts cytoskeletal organization
- Induces reversible myotube fragmentation in model systems
- Relevant to muscle regeneration and angiogenesis research
Applications
- Tubulin polymerization assays
- Cytoskeletal remodeling studies
- Skeletal muscle regeneration models
- Angiogenesis and cell morphology research
More Information
| Parent CAS No. | 267402-71-1 |
|---|---|
| Chemical Name | 9-Isopropyl-N*2*,N*6*-bis-(4-methoxy-benzyl)-9H-purine-2,6-diamine |
| SMILES | N1C(NCC2C=CC(OC)=CC=2)=C2N=CN(C(C)C)C2=NC=1NCC1C=CC(OC)=CC=1 |
| MFCD | MFCD02683596 |
| InChi | InChI=1S/C24H28N6O2/c1-16(2)30-15-27-21-22(25-13-17-5-9-19(31-3)10-6-17)28-24(29-23(21)30)26-14-18-7-11-20(32-4)12-8-18/h5-12,15-16H,13-14H2,1-4H3,(H2,25,26,28,29) |
| InChiKey | IDCOTQWQVPRTNK-UHFFFAOYSA-N |
| CID | 4273 |
| Short Description | Tubulin inhibitor |
References
- GR Rosania et al. Myoseverin, a novel microtubule-binding molecule with novel cellular effects. Nat. Biotechnol. 2000, 18, 307-308.
- OD Perez et al. Inhibition and reversal of myogenic differentiation by purine-based microtuble assembly inhibitors. Chem. Biol. 2002, 9, 475-483.
- HE Park et al. Myoseverin Is a Potential Angiogenesis Inhibitor by Inhibiting Endothelial Cell Function and Endothelial Progenitor Cell Differentiation. DNA and Cell Biol. 2006, 25(9), 514-522.
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