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HTI 286
- SPA 110 - Taltobulin
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C27H43N3O4
- MW: 473.65
Description
More Information
| Parent CAS No. | 228266-40-8 |
|---|---|
| Chemical Name | (S,E)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enoic acid |
| SMILES | C(=O)([C@H](C(C)(C)C)NC(=O)[C@@H](NC)C(C)(C)C1C=CC=CC=1)N(C)[C@@H](C(C)C)/C=C(C)/C(O)=O |&1:2,10,24,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C27H43N3O4/c1-17(2)20(16-18(3)25(33)34)30(10)24(32)22(26(4,5)6)29-23(31)21(28-9)27(7,8)19-14-12-11-13-15-19/h11-17,20-22,28H,1-10H3,(H,29,31)(H,33,34)/b18-16+/t20-,21-,22-/m1/s1 |
| InChiKey | CNTMOLDWXSVYKD-PSRNMDMQSA-N |
| CID | 6918637 |
| Short Description | Tubulin inhibitor |
References
- F Loganzo et al. HTI-286, a Synthetic Analogue of the Tripeptide Hemiasterlin, Is a Potent Antimicrotubule Agent that Circumvents P-Glycoprotein-mediated Resistance in Vitro and in Vivo. Cancer Res. 2003, 63, 1838.
- C Redaelli et al. Synthetic tubulin inhibitor HTI-286 and hepatocellular carcinoma: an in-vitro and and in-vivo study. J. Clin. Oncol. (Meeting Abstracts) 2005, 23(16S), 4201.
- BA Hadaschik et al. Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin. Int. J. Cancer. 2008, 122(10), 2368-2376.
- Y Matsui et al. Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer. Mol. Cancer Ther. 2009, 8(8), 2402-2411.
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