Bulk Inquiry
PVHD121
- Soluble in DMSO
- MF: C17H16N2O2
- MW: 280.32
Description
PVHD121 is a potent mitotic inhibitor, an antimitotic agent that selectively disturbs microtubule formation at centrosomes during mitosis. PVHD121 was shown to have strong antiproliferative activity against various tumor-derived cell lines, including A549 (lung), NCI-H460 (lung), HCT116 (colon), MCF7 (breast), PC3 (prostate), and HeLa (cervical) cells with IC50 values from 0.1 to 0.3 μM. Potential tool for studying the molecular biology of mitosis.
More Information
| Parent CAS No. | 187336-16-9 |
|---|---|
| Chemical Name | 1-(4-Methoxyphenyl)-1-(quinazolin-4-yl)ethanol |
| SMILES | C1C=C2C(C(C)(O)C3C=CC(OC)=CC=3)=NC=NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H16N2O2/c1-17(20,12-7-9-13(21-2)10-8-12)16-14-5-3-4-6-15(14)18-11-19-16/h3-11,20H,1-2H3 |
| InChiKey | WGDUWVWCDNCAOT-UHFFFAOYSA-N |
| CID | 10826594 |
| Short Description | Microtubule inhibitor |
References
- K Kuroiwa et al. Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents. ACS Med Chem Lett. 2015 Jan 10;6(3):287-91.
- JI Sawada et al. Selective Inhibition of Spindle Microtubules by a Tubulin-Binding Quinazoline Derivative. Mol Pharmacol. 2019;96(5):609-618.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1233 | Combretastatin-A4 |
From $93.50 |
| 1310 | Myoseverin |
From $137.50 |
| 1650 | HTI 286 |
From $154.00 |
| 2398 | Suprafenacine |
From $121.00 |
| 2658 | MPT0B098 |
From $121.00 |
| 2815 | SP-6-27 |
From $137.50 |
| 2816 | WX-132-18B |
From $126.50 |
| 2916 | Cevipabulin |
From $154.00 |
| 3243 | CK-666 |
From $110.00 |
| 3368 | Podophyllotoxin |
From $44.00 |
| 3371 | Colchicine |
From $55.00 |
| 3400 | Tubulin inhibitor 6 |
From $99.00 |
| 3804 | Sabizabulin |
From $242.00 |
