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Colchicine
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C22H25NO6
- MW: 399.44
Description
Colchicine is a classical anti-mitotic drug which blocks mitotic cells in metaphase. It binds to soluble tubulin to form tubulin-colchicine complexes in a poorly reversible manner, which then binds to the ends of microtubules to prevent the elongation of the microtubule polymer.
More Information
| Parent CAS No. | 64-86-8 |
|---|---|
| Chemical Name | N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
| SMILES | C1(OC)C(OC)=CC2CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C3C=2C=1OC |&1:10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
| InChiKey | IAKHMKGGTNLKSZ-INIZCTEOSA-N |
| CID | 6167 |
| Short Description | Tubulin inhibitor |
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