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Suprafenacine
- SRF
- Soluble in DMSO
- MF: C16H18N4O
- MW: 282.34
Description
Suprafenacine is a microtubule destabilizer with an IC50 value of 0.38 μM for inhibition of microtubule polymerization. It causes G2/M cell-cycle arrest and apoptosis, inhibits proliferation across cancer cell lines with IC50 values of 83–381 nM, and can bypass P-glycoprotein-mediated multidrug resistance.
Microtubule dynamics are essential for mitosis and remain a central vulnerability in anticancer pharmacology. Suprafenacine is useful for studying tubulin inhibition, mitotic arrest and drug-resistance bypass mechanisms.
Key Features
- Microtubule destabilizing tubulin inhibitor
- IC50: 0.38 μM for microtubule polymerization inhibition
- Induces G2/M arrest and apoptosis
- Bypasses P-glycoprotein-mediated resistance in reported models
Applications
- Tubulin pharmacology
- Mitotic arrest studies
- Cancer proliferation assays
- Multidrug resistance model research
More Information
| Parent CAS No. | 1477482-50-0 |
|---|---|
| Chemical Name | (E)-N'-(4-methylbenzylidene)-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide |
| SMILES | N1C2=C(CCCC2)C(C(N/N=C/C2=CC=C(C)C=C2)=O)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H18N4O/c1-11-6-8-12(9-7-11)10-17-20-16(21)15-13-4-2-3-5-14(13)18-19-15/h6-10H,2-5H2,1H3,(H,18,19)(H,20,21)/b17-10+ |
| InChiKey | WKKLZIQHOXPLLZ-LICLKQGHSA-N |
| CID | 6861947 |
| Short Description | Tubulin inhibitor |
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