Bulk Inquiry
MPT0B098
- Soluble in DMSO
- MF: C20H18N2O3S
- MW: 366.43
Description
Microtubule inhibitor that binds to the colchicine-binding site of tubulin and suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability. MPT0B098 arrests cells in the G2-M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. MPT0B098 not only inhibited the expression levels of HIF-1α protein but also destabilized HIF-1α mRNA.
More Information
| Parent CAS No. | 1254363-89-7 |
|---|---|
| Chemical Name | 1-(4-methoxyphenylsulfonyl)-7-(pyridin-4-yl)indoline |
| SMILES | N1(S(C2=CC=C(OC)C=C2)(=O)=O)C2=C(C=CC=C2C2C=CN=CC=2)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H18N2O3S/c1-25-17-5-7-18(8-6-17)26(23,24)22-14-11-16-3-2-4-19(20(16)22)15-9-12-21-13-10-15/h2-10,12-13H,11,14H2,1H3 |
| InChiKey | AGYCYVPAEQVWJT-UHFFFAOYSA-N |
| CID | 50898338 |
| Short Description | Microtubule inhibitor |
References
- YC Cheng et al. MPT0B098, a novel microtubule inhibitor that destabilizes the hypoxia-inducible factor-1α mRNA through decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR. Mol Cancer Ther. 2013 Jul;12(7):1202-12.
- JY Chang et al. Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents. Med. Chem. Commun., 2010, 1, 152-155.
- HY Peng et al. MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma. PLoS One. 2016 Jul 1;11(7):e0158440.
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