Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

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Axon ID Name Description From price
1966 AZD 5438 CDK inhibitor (1, 2, and 9 specific) €80.00
1399 AZD 7762 hydrochloride CHK inhibitor €60.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €105.00
2918 BAY 1895344 Potent, orally available and highly selective inhibitor of ATR protein kinase €100.00
2635 BAY-598 Selective inhibitor of SMYD2 €110.00
2735 BCI-121 Inhibitor of SMYD3 €90.00
1828 BH3I 1 Inhibitor of Bcl-2 family protein €125.00
1129 BI 2536 PLK1 inhibitor €60.00
1473 BI 6727 PLK1 Inhibitor €90.00
1692 BIX 01294 trihydrochloride HMTase inhibitor (G9a and G9a-like protein) €80.00
2462 BMH 21 Inhibitor of RNA Polymerase I (RNAP1) €95.00
2397 BQU 57 Inhibitor of the RAS-like small GTPases RalA and RalB €125.00
2471 BRD 73954 Dual HDAC 6/8 inhibitor with excellent selectivity over the other HDACs €85.00
2334 BT2 Allosteric inhibitor of BCKDC kinase (BDK) and Mcl-1 inhibitor €95.00
2407 BTB 1 The first small molecule reversible inhibitor of the mitotic motor protein Kif18A €70.00

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