Cell Cycle Regulation

This class of Axon Ligands™ consists of compounds that affect the processes occurring in eukaryatic cells responsible for cell replication. Cells that are not in a quiescent state exist in either 1 of the 4 known stages of cell duplication: G1, S, G2, or M. The first 3 stages (G1, S, G2) together form the so-called “Interphase” during which the cell increases in size, accumulates required nutrients, and replicates the DNA in the cell nucleus. The correctness of these complex processes is evaluated at checkpoints at the end of each of the individual stages. If all checkpoints are passed successfully, the cell cycle enters the stage of the actual cell division/mitosis[1]. During mitoses, again, 4 distinct phases can be discriminated as pro-, meta-, ana-, and telephase.


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.

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Axon ID Name Description From price
2795 AZD 1208 Pim kinase inhibitor €70.00
1464 AZD 2281 PARP inhibitor €55.00
2241 AZD 2461 PARP inhibitor with poor P-glycoprotein substrate qualities €95.00
1966 AZD 5438 CDK inhibitor (1, 2, and 9 specific) €80.00
1399 AZD 7762 hydrochloride CHK inhibitor €60.00
2981 B106 Potent and selective PKC-δ inhibitor €135.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €105.00
2918 BAY 1895344 Potent, orally available and highly selective inhibitor of ATR protein kinase €100.00
2635 BAY-598 Selective inhibitor of SMYD2 €110.00
2735 BCI-121 Inhibitor of SMYD3 €90.00
3115 Belinostat HDAC inhibitor  Recently added €70.00
1828 BH3I 1 Inhibitor of Bcl-2 family protein €125.00
1129 BI 2536 PLK1 inhibitor €60.00
1473 BI 6727 PLK1 Inhibitor €90.00
3047 BI-6C9 Inhibitor of BID protein €145.00

Items 31 to 45 of 290 total

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